The fact hasn’t found a cure for PBS yet, nor can they tell whether people will respond to some treatments. The good news on bladder pain especially Painful Bladder Syndrome, is that in more than. When symptoms disappear because of a change in diet or other treatments are employed, they may return after a few days, weeks, months, or even years. Unfortunately, scientists have no idea why. The severity of your bladder pain may mean trying a combination of different treatment options to see what works best for you. It also makes sense to discuss your options with your doctor. Treatment options might include a combination of both lifestyle changes and medical treatments.