Surgical care is entering a period in which scientific discovery, engineering expertise, and clinical practice increasingly influence one another. Against this background, the Global Surgical Science and Technology Conference, GSST 2027, (Hybrid Event) will take place from June 14–16, 2027, in Rome, Italy, with online participation available as part of its hybrid format. The Surgery Conference provides an opportunity to examine how advances in science and technology are reshaping the way surgical problems are studied, managed, and addressed. Research discussions may extend from developments in operative techniques and medical devices to improvements in imaging, precision, digital systems, patient monitoring, and technology-supported clinical decision-making. For investigators, surgeons, healthcare professionals, engineers, technology specialists, educators, and representatives from related fields, the conference creates space to exchange knowledge from different areas of expertise. Presentations can contribute perspectives on laboratory investigations, clinical experiences, emerging technologies, methodological developments, and practical challenges encountered in modern surgical care. Another important aspect of Surgical Science Conferences is the interaction between established approaches and emerging possibilities. Discussions surrounding technological advancement can help identify areas requiring further investigation while encouraging collaboration between disciplines that traditionally operate within separate professional boundaries. Rome will provide the in-person setting for the meeting, while the online component allows wider participation beyond the physical venue. This combination supports knowledge exchange among attendees with different professional backgrounds and geographic locations. Surgery Conference 2027 therefore serves as a meeting point for contemporary surgical science, technological development, and clinical knowledge, encouraging continued discussion about how innovation can contribute to the future direction of surgical practice.